zhaosf-乳糖引起的肠球菌扩增促进移植物抗宿主病

时间:2019-11-29 16:40 来源: www.seosem.ws

本期文章:《科学》:Volume 366 Issue 6469

美国纪念斯隆凯特琳癌症研究中心M. R. M. van den Brink、J. U. Peled等研究人员合作发现,乳糖引起肠球菌扩增,从而促进移植物抗宿主病(GVHD)。相关论文于2019年11月28日发表于国际学术期刊《科学》。

在接受同种异体造血细胞移植(allo-HCT)的患者中,研究人员描述了肠球菌扩增的高发生率,这与GVHD和死亡率相关。研究人员发现,allo-HCT后,肠球菌还在小鼠胃肠道中扩增,并在致癌菌模型中加剧了疾病的严重性。

肠球菌的生长依赖于二糖——乳糖,饮食中的乳糖消耗会减少肠球菌的生长并降低小鼠GVHD的严重程度。携带乳糖不吸收基因型的allo-HCT患者表现出抗生素后肠球菌清除不足。

研究人员发现,乳糖这种常见的营养素能够引发共生细菌的扩增,从而加剧肠道和全身性炎症性疾病。

据介绍,肠道微生物群落的破坏似乎是许多人类疾病的根源,但促进这种生态失调及其不良后果的机制却鲜为人知。

附:英文原文

Title: Lactose drives Enterococcus expansion to promote graft-versus-host disease

Author: C. K. Stein-Thoeringer, K. B. Nichols, A. Lazrak, M. D. Docampo, A. E. Slingerland, J. B. Slingerland, A. G. Clurman, G. Armijo, A. L. C. Gomes, Y. Shono, A. Staffas, M. Burgos da Silva, S. M. Devlin, K. A. Markey, D. Bajic, R. Pinedo, A. Tsakmaklis, E. R. Littmann, A. Pastore, Y. Taur, S. Monette, M. E. Arcila, A. J. Pickard, M. Maloy, R. J. Wright, L. A. Amoretti, E. Fontana, D. Pham, M. A. Jamal, D. Weber, A. D. Sung, D. Hashimoto, C. Scheid, J. B. Xavier, J. A. Messina, K. Romero, M. Lew, A. Bush, L. Bohannon, K. Hayasaka, Y. Hasegawa, M. J. G. T. Vehreschild, J. R. Cross, D. M. Ponce, M. A. Perales, S. A. Giralt, R. R. Jenq, T. Teshima, E. Holler

Issue&Volume: 2019/11/29

Abstract: Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that Enterococcus also expands in the mouse gastrointestinal tract after allo-HCT and exacerbates disease severity in gnotobiotic models. Enterococcus growth is dependent on the disaccharide lactose, and dietary lactose depletion attenuates Enterococcus outgrowth and reduces the severity of GVHD in mice. Allo-HCT patients carrying lactose-nonabsorber genotypes showed compromised clearance of postantibiotic Enterococcus domination. We report lactose as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease.

DOI: 10.1126/science.aax3760

Source: https://science.sciencemag.org/content/366/6469/1143

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/